Question

Alfred Gilman restored the activity of this enzyme in “uncoupled” mutants using cell extracts later found to contain a factor predicted by Martin Rodbell. This enzyme is activated by fluoride, which binds magnesium atoms in the cleft between its C1 and C2 domains. A tetraphosphate group allows dideoxypurines (“di-deoxy-purines”) to inhibit this enzyme by binding its P-site. This enzyme is often crystallized while bound to forskolin (10[2])(“FOR-skuh-lin”). Study of this enzyme’s (10[2])interactions with the beta-2 (10[1])adrenergic (10[1])(“ad-ree-NER-jick”) receptor led to the description of G proteins. Immune response to pertussis is suppressed by ADP-ribosylation of G-sub-i alpha, which depresses the activity of this enzyme and suppresses the (10[1])major [emphasize] alternative to the phosphoinositol (“phospho-in-OSS-uh-toll”) signaling pathway. For 10 points, name this enzyme that generates the secondary messenger (10[1]-5[2])cAMP (10[5])(“c-A-M-P”) from ATP. (10[1])■END■ (10[2]0[9])

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