Question

Cells performing this process have a chance to kill themselves by targeting “like S-gamma” regions past the alpha-2 exon, which will “loop out” an entire locus. Errors in this process cause translocation of c-myc [emphasize] downstream of J sub H, the most common mutation (-5[1])in Burkitt lymphoma. (-5[2])This process excises a ring of DNA with up to seven exons preceding the C-alpha gene. (-5[1])S-regions are joined together during this process, (-5[1])which borrows endonucleases (“endo-NOO-klee-aces”) from base excision repair to cleave abasic (-5[2])(“AY-basic”) sites formed by cytidine deaminase (“dee-AM-in-ace”), diverting them from somatic hypermutation. (-5[2])This process (-5[1])follows VDJ (-5[1])recombination (-5[1])in an activated B (-5[1])cell and can change the expressed constant region from mu to gamma-3 or gamma-1. For 10 (10[1])points, name this (-5[1])process that swaps out the heavy chain to allow expression of immunoglobulins other than IgM. (0[1])■END■ (10[3]0[11])

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