Question

In an example of this state, three sequential transcriptional programs hijack NF-kappa B signaling with LMP1 to generate an in vivo immortal cell line. MicroRNAs that maintain this state are expressed by the BHRF1 and BART gene clusters. Episomal DNA undergoes chromatinization with host histones during this state, producing epigenetic silencing as an escape mechanism. In some populations, this state can be identified by accumulation of the LAT intron. Entering this state requires suppression of early genes (10[1])and can be viewed as a form of bet-hedging due to its (10[1])creation of a drug-resistant reservoir in long-lived (-5[1])cells like neurons of the dorsal root ganglia. (-5[1])Stress-triggered (10[1])reactivation can end this state, producing (-5[1])outbreaks (-5[1])of (-5[1])shingles or cold (-5[1])sores. (10[1])For (10[1])10 points, (-5[1])name this form (-5[1])of dormancy assumed by viruses (-5[2])not actively undergoing the lytic (10[1])cycle. (10[1])■END■ (10[9]0[6])

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Summary